MBL2Variations and Malaria Susceptibility in Indian Populations

MBL2 variations and malaria susceptibility in Indian populations.

Human mannose-binding lectin (MBL) encoded by the MBL2 gene is a pattern recognition protein and has been associated with many infectious diseases, including malaria. We sought to investigate the contribution of functional MBL2 gene variations to Plasmodium falciparum malaria in well-defined cases and in matched controls. We resequenced the 8.7 kb of the entire MBL2 gene in 434 individuals clin...

Polymorphism analysis of malaria susceptibility biomarkers in G6PD deficiency patients

  Abstract   Background: Several studies suggested that some traits and polymorphisms in human genome such as G6PD deficiency and other genes have protective effects on susceptibility to malaria infection .   Methods: In present study we investigated the prevalence of TNF [1] -244GgA, TNF [1] -   308 GgA,TNF [1] -238GgA, NOS2-954GgC, MBL54GgA, MBL 57GgA, MBL IVSI -   5 GgA polymorphisms and G6P...

Tebetren in Indian Strains of Malaria

Prontosil in Indian Strains of Malaria

The discovery of antimalarial properties ni Plasmochin and acridine derivatives such -is '?tebrin is undoubtedly a great advance in the herapy of malaria. The untoward symptoms which are occasionally observed, their inability to prevent relapses in a certain percentage of cases and their not having a true prophylactic a?tion, inasmuch as they have no action on the ?P?rozoites injected by the mo...

Crinodora (Palusan) in Indian Strains of Malaria

After the synthesis and successful trials of atebrin in the treatment of malaria, a number of acridine derivatives closely resembling it in chemical composition and properties were prepared. In France, ' quinacrine ' was synthesized and in the U.S.S.R. 1 acriquineSoon after, S. A. Farmaceutici Italia Milano synthesized a similar compound which they called ' Palusan' and later ' Crinodora ', the...